炎症信号通道与前列腺癌关系的研究进展

摘要

In the normal prostate epithelium,the androgen can suppress the occurrence and progression of prostste cancer through up-regulating anti-tumor acute inflammation and down-regulating pro-tumor chronic inflammation pathway. Once the regulation is imhalance, it will promote the initiation and development of prostste cancer. Therefore, the investigation into the pathogenesis of the regulated-imbalance is critical for the prevention and treatment of prostste cancer. Here is to summarize the correlation between the two pathways and prostate cancer.%在正常前列腺上皮中,雄激素通过上调干扰素介导的急性炎症信号通道和下调白细胞介素介导的慢性炎症信号通道来抑制前列腺癌的发生、发展.一旦雄激素调节的急慢性炎症信号通道发生失衡,则会促进前列腺癌的形成及进展.揭示这种失衡的发生机制是预防和治疗前列腺癌的关键.现就上述两种炎症信号通道与前列腺癌的关系予以综述.