EV71感染致神经源性肺水肿的诊治进展

摘要

Enterovirus 71( EV71 )is a type of human enterovirus which is the major pathogen of severe cases of hand-foot-mouth disease. After EV71 infection, severe cases may have the symptom of neurogenic pulmonary edema and pulmonary hemorrhage. The pathogenesis may be related to the comprehensive influence on hemodynamics and pulmonary capillary permeability fom multiple bioactive substances and neural factors after the central nervous system is damaged. The disease progresses quickly with no specific early clinical manifestations which requires for dynamic clinical observation, early detection and timely treatment.%肠道病毒71型(EV71)是人类肠道病毒的一种,是手足口病重症病例的主要病原体,EV71感染后严重病例可出现神经源性肺水肿、肺出血.其发病机制可能与中枢神经系统损害后多种生物活性物质以及神经因素对血流动力学和肺毛细血管渗透性的综合影响有关,早期临床表现无特异性而进展迅速,需临床动态观察、早期发现、及早采取综合治疗措施.