蛛网膜下腔出血后早期脑损伤的研究进展

摘要

动脉瘤性蛛网膜下腔出血(SAH)是一种严重的疾病,具有很高的病死率和致残率.然而,传统的针对迟发性脑血管痉挛的治疗却不能取得很好的效果.最新研究认为,早期脑损伤(EBI)可能才是决定SAH患者预后的主要原因.EBI的发病机制是一系列复杂的病理、生理变化,主要包括全脑缺血、血脑屏障的破坏、脑水肿、氧化应激反应、免疫炎症途径和细胞死亡途径等.%Aneurysmal subarachnoid hemorrhage( SAH ) is a devastating disease with high mortality and disability. Traditional treatment focused on the delayed cerebral vasospasm following SAH didn't achieve good effect. Recent studies suggest that early brain injury( EBI ) may be the major cause of poor prognosis in patients with SAH. The pathogenesis of EBI is a series of complicated pathophysiological changes,including cerebral ischemia, the disruption of blood brain barrier, cerebral edema, oxidative stress, the pathways of inflammation and cell death,and so on.