三种消化道恶性肿瘤小肠细菌过度生长情况的研究

摘要

Objective To study the small intestinal bacterial overgrowth ( SIBO ) in patients with esophageal cancer,gastric cancer,and liver cancer. Methods Patients with gastrointestinal malignancies ( n = 168 ) were divided to three groups, namely, esophageal cancer group, gastric cancer group, and liver cancer group. Glucose hydrogen breath test was used to examine the SIBO profile,controlled by that from healthy volunteers. Results The three patient groups had a significantly different SIBO positive rate and expiratory hydrogen concentration from control subjects ( P ＜ 0.01 ). Liver cancer patients had a significantly higher SIBO positive rate and expiratory hydrogen concentration than the other two groups ( P ＜ 0.05 ). Conclusion Patients with gastrointestinal malignancy are prone to SIBO,especially those with liver cancer. GHBT is helpful for the diagnosis of SIBO,the interpretation of some clinical symptoms and guide the adjustment of medication.%目的 探讨食管癌、胃癌、肝癌三种消化道恶性肿瘤小肠细菌过生长(SIBO)的情况.方法 将168例消化道恶性肿瘤患者分为食管癌组、胃癌组、肝癌组三组,通过葡萄糖氢呼气试验(GHBT)分别检测其SIBO情况,并与健康对照组进行组间比较分析.结果 三组消化道恶性肿瘤患者与健康对照组的SIBO阳性率及试餐后呼气氢浓度比较差异均有统计学意义(P＜0.01).肝癌组患者的SIBO阳性率及试餐后呼气氢浓度较食管癌组和胃癌组明显增高,比较差异有统计学意义(P＜0.05).结论 消化道恶性肿瘤患者容易发生SIBO,特别是肝癌患者尤为明显,通过呼气氢浓度检测,可及时诊断SIBO,有利于解释疾病的部分临床症状,指导调整治疗用药.