Nanog基因是2003年报道的在囊胚期的内细胞团、原始生殖细胞以及胚胎干细胞表达的新转录因子,它对维持胚胎干细胞自我增殖和亚全能性起关键性作用,对其的研究将对发育生物学基础研究、再生医学的发展以及新药的开发产生深远的影响.通过近年来对Nanog基因在胚胎干细胞、体细胞、肿瘤细胞的表达和作用机制的研究,推测Nanog基因的表达调控与癌症的发生、发展有关,对未来的肿瘤研究趋势予以展望.通过深入研究Nanog基因的表达及其调控机制有助于探索控制和治疗癌症的新方法.%Nanog gene is a new transcription factor reported in 2003 to be expressed in blastular inner cell mass, primitive germ cells and embryonic stem cells. Nanog plays a crucial role in the maintenance of self-renewal and pluripotency of embryonic stem cells. The research of Nanog is of great significance for developmental biology,regenerative medicine, and development of new drugs. Recently, Nanog gene has been extensively studied for its expression and mechanism of action in embryonic stem cells,somatic cells, and tumor cells. The regulation of Nanog gene is predicted to be associated with the occurrence and progress of cancer,as a promising target for prospective tumor treatment. The further investigation into the expression and regulation mechanism of Nanog gene helps to explore the novel preventive and therapeutic regimens of cancer.
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