放射性肠炎发生机制的研究进展

摘要

Radiation enteritis( RE) is a common serious complication in patients receiving abdominal or pelvic irradiation in the course of cancer treatment.During the process of receiving abdominal or pelvic irradiation , about 60％ ～ 70％ patients have developed acute gastrointestinal symptoms.The incidence of RE is closely related to the radiation dose, divided dose, time interval between radiation therapy, radiation scope, and location.It mainly impairs the function of mechanical gut barrier,immune barrier,chemical barrier,and biological barrier.In this paper,we reviews the definition,pathology,and the development on the pathogenesis of RE,mainly introducing the pathogenesis of intestinal barrier dysfunction.%放射性肠炎(RE)是腹盆腔原发或继发恶性肿瘤患者进行放疗的一种常见严重并发症.在对腹盆腔恶性肿瘤进行放疗过程中,有60% ～70%的患者出现急性胃肠道不适症状.RE的发生与放射剂量、分割剂量、放疗间隔时间、放射范围及部位密切相关,主要通过放射线作用于肠道后引起肠道机械屏障、免疫屏障、化学屏障及生物屏障功能受损,但目前对其确切发病机制尚不十分清楚.现就RE的定义、病理改变、发生机制及最新研究进展予以综述,重点综述放疗导致肠道各屏障功能障碍的发生机制.