Graves甲状腺功能亢进合并肝损伤与甲状腺自身抗体相关性研究

摘要

目的 探讨甲状腺自身抗体[甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)]与Graves甲状腺功能亢进合并肝损伤的关系.方法 采用放射免疫法检测24例Graves甲状腺功能亢进合并肝损伤患者及24例肝功能正常的Craves甲状腺功能亢进患者的TPOAb、TGAb水平,并将肝功能指标与TPOAb、TGAb水平进行相关性分析.结果 Craves甲状腺功能亢进合并肝损伤患者的TPOAb、TGAb水平略高于肝功能正常的Graves甲状腺功能亢进患者(P＞0.05);Craves甲状腺功能亢进患者的肝功能指标与TPOAb、TGAb无相关性(P＞0.05).结论 TPOAb、TGAb水平与Graves甲状腺功能亢进合并肝损伤无相关性.%Objective To explore the correlation between thyroid autoantibodies [ thyroid peroxidase antibodies (TPOAb), thyroid globulin antibody (TGAb)] and Graves hyperthyroidism combined with liver damage. Methods The radiation immune method was used to detect TPOAb, TGAb level of 24 patients with Graves hyperthyroidism combined with liver injury and 24 cases Graves hyperthyroidism with normal liver function,and correlation analysis on TPOAb,TGAb with liver function index was done. Results TPOAb , TGAb level of patients of Graves hyperthyroidism combined with liver injury were slightly higher than that of patients of hyperthyroidism Graves with normal liver function,the difference was not statistically significant (P ＞0.05). TPOAb and TGAb and liver function index of patients with Graves hyperthyroidism were not correlated(P ＞0. 05). Conclusion There's no correlation between TPOAb,TGAb level and Graves hyperthyroidism combined with liver damage.