体外扩增和纯化脂肪干细胞应用于自体脂肪移植的研究进展

摘要

脂肪移植后脂肪组织颗粒存在高吸收率和低存活率的问题,至今仍无突破性的进展.脂肪干细胞有着来源广泛、含量丰富、分离简单、体外扩增稳定容易,并有分泌细胞因子促进血管形成和多向分化潜能等优势.随着研究的深入,脂肪干细胞辅助一起进行脂肪移植,可以有效预防移植后脂肪组织的萎缩.现对脂肪干细胞辅助的脂肪移植予以综述.%Because of the high absorptivity and the low livability, there is no breakthrough in the fat par-:icle auto-transplantation up to now. Adipose-deliver! stem cells( ADSCs )have lots of advantages in the abundant sources, easy separation, and steady amplification in vitro. Furthermore, it can secrete cell factors to promote angiogenesis and have the potential to differentiate into many types of tissues. Along the deeper exploration, a better transplantation effect could be obtained from implanting the fat particles mixed with ADSCs, which can prevent the fat particles form atrophy. Here is to make a review on the advances in this field.