丙泊酚诱导血管内皮细胞中eNOS激活机制的最新研究进展

摘要

Propofol is one of the most rommonly used drugs for anesthesia induction and maintenance inrnac reserve. Propofol has been repoited to affect arterial and venous rirmlation both in vivo and in vitro. Propofol pe,e,mp to affert many ceilulai' and molerulai' processes oi the vasnilai' system, such as calcium signaling,rnon the mechanisms of propofol induced activation of eNOS in endothelial cells.%丙泊酚是目前临床上用于麻醉诱导和维持最常用的药物之一,但是常伴血压降低,这对心脏储备低下的患者极为有害.丙泊酚的血管效应复杂,在体实验显示,丙泊酚对动静脉循环都有影响.丙泊酚似乎影响血管系统的许多细胞分子过程,如钙信号、内皮功能和交感神经传递等.现探讨丙泊酚诱导血管内皮细胞中内皮型一氧化氮合酶激活的机制,以期为实验研究提供参考.