In recent years, the vasoactive effect of Genistein has drawn more and more attention. The present study show that genistein regulates vascular smooth muscle contraction and relaxation by endothelium-dependent and endothelium-independent vasomotor system, which involve genomic and non-genomic mechanisms. Genistein can also act with estrogen receptor through multiple signal transduction pathways playing estrogen-like role. In addition, genistein can act in the kidney, increasing renal blood flow and urinary sodium excretion. Genistein also plays a role in body fluid regulation system such as the renin-angiotensin system. The animal studies data indicate that the synergy of above functions can achieve the antihypertensive effect.%近年来,Genistein(金雀异黄素/染料木素)的血管活性作用越来越受到的重视.目前研究表明,Genistein可通过内皮依赖性和内皮非依赖性血管舒缩系统调节血管平滑肌舒缩,这些影响涉及基因组和非基因组机制.Genistein还可与雌激素受体相互作用,通过多信号转导通路发挥类雌激素作用.另外,Genistein可作用于肾脏,增加肾血流量及尿钠排泄.Genistein也可针对体液调节系统(如肾素-血管紧张素系统)发挥作用.动物研究数据显示,以上作用相互协同可以达到降压的效果.
展开▼
