Protein kinase plays an important role in the development of tumor, and the development oi kinase inhibitor with protein kinase as the target point has become the hot spot oi the drug research and application in recent years. With their high selectivity and less side effects,tyrosine kinaie inhibitors exhibit their superiority over the traditional pharmacological therapy in the treatment oi chronic myelogenous leukemia,gastrointestinal stromal tumors, non-small cell lung cancer, hepat ocellular carcinoma, renal cell cancer and other diseases, some oi them have already become the first-line treatment for tumors.%蛋白激酶在肿瘤发生、发展过程中起重要作用,以其为药物靶点的激酶抑制剂成为近年药物研发与应用的热点.酪氨酸激酶抑制剂具有高选择性、不良反应少的特点,在慢性粒细胞白血病、胃肠间质瘤、非小细胞肺癌、肝细胞癌、肾细胞癌等多种疾病治疗中显示出较传统治疗药物的优越性,部分已成为治疗肿瘤的一线用药.
展开▼
