Warfarin is widely used to control thromhoembolism in patients with atrial fibrillation which is the most effective oral anticoagulant utilized so far. It has a narrow therapeutic range but a large individual variation and the curative effect is influenced by many factors, which may lead to insufficient curative effect or bleeding, or even fatal bleeding. The rational and safe use of warfarin has become a key problem in clinical practice. The efficacy of warfarin is affected by many factors, and the genetic polymorphism of hereditary factors is prominent. Here is to make a review on the effects of genetic polymorphisms, such as cytochrome P4502C9 and vitamin K epoxide reducetase, on drug response and therapeutic efficacy of warfarin for patients with atrial fibrillation%目前,华法林是临床上广泛用来防治心房颤动患者血栓栓塞并发症的、最有效的口服抗凝药物,但其治疗窗窄,个体差异大,影响因素复杂,易导致疗效不足或出血,甚至致死性出血的并发症.如何合理、安全、有效地使用华法林成为目前国内外研究者的重点和难点;且疗效受多种因素的影响,以遗传因素中基因多态性较为突出.现从基因角度综述细胞色素P4502C9和维生素K环氧化物还原酶基因多态性对心房颤动患者华法林药反应差异的影响.
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