Objective To investigate the relationship of the female apheresis platelet donors' sodium citrate toxic reaction and the anticoagulant concentration. Methods 181 cases of female platelet donors at blood center were randomly divided into group A of 80 cases and group B. Of 101 cases, sodium citrate poisoning cases in anticoagulant/blood ratio of 1:10( group A)and 1: 11( group B )female platelet donors were observed and compared. Results When the ratio of anticoagulant and whole blood was 1=11,1.98% of the female donors of group B had sodium citrate toxicity reactions, which was significantly lower than group A with the ratio of anticoagulant and whole blood 1: 10. The difference of incidence of sodium toxic reactions was statistically significant( P <0. 05 ). Conclusion Women in Jiangsu Province generally have smaller body weight,the use of appropriate anticoagulant concentration( the ratio of anticoagulant and whole blood 1 : 11 )can significantly reduce the incidence of sodium citrate toxic reaction of the female apheresis platelet donors, which has important application value.%目的 探讨女性机采血小板献血者枸橼酸钠中毒与抗凝剂比例的关系.方法 对来血液中心进行机采血小板的181例女性献血者随机分为A组80例,B组101例.对比观察抗凝剂与全血比例为1:10(A组)和1:11时(B组)女性机采血小板献血者发生枸橼酸钠中毒的情况.结果 抗凝剂与全血比例为1:11的B组女性献血者枸橼酸钠中毒反应发生率为1.98%,明显低于抗凝剂与全血比例为1:10的A组女性献血者,比较差异有统计学意义(P＜0.05).结论 江苏地区女性体质量普遍较轻,采用抗凝剂与全血比例为1:11可明显改善女性机采血小板献血者枸橼酸钠中毒反应的发生率,具有重要的应用价值.
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