抗CCP抗体、抗Sa抗体和类风湿因子在早期类风湿关节炎中的诊断价值

摘要

目的 研究抗环瓜氨酸肽抗体(抗CCP抗体)、抗Sa抗体与类风湿因子(RF)在早期类风湿关节炎(RA)诊断中的意义.方法 收集2011年1月至12月在解放军四五二医院住院的RA患者151例及同期在该医院做健康体检的健康人员93例的血清标本,分别检测其抗CCP抗体、抗Sa抗体和RF的水平,并对检测数据进行统计分析,探讨其诊断RA的灵敏度及特异度.结果 抗CCP抗体+抗Sa抗体+ RF三项联合检测的灵敏度及特异度分别与抗CCP抗体、抗Sa抗体以及RF单项检测比较,差异均具有统计学意义(P＜0.05);病程＜1年的RA患者,其抗CCP抗体+抗Sa抗体+RF联合检测的灵敏度为95.6%;病程≥1年的灵敏度为90.4%,两者比较差异有统计学意义(P＜0.05).结论 抗CCP抗体、抗Sa抗体和RF是早期诊断RA较好的指标,三者联合检测能提高检测灵敏度及诊断率,适用于早期RA的筛查诊断.%Objective To study the clinical significance of anti-CCP antibody ,anti-Sa antibody and RF in early rheumatoid arthritis ( RA ) diagnosis.Methods The serum samples of 151 patients with rheumatoid arthritis,93 cases of the healthy controls from PLA 452 Hospital during Jan.2011 and Dec.2011 were collected and then detected anti-CCP antibody ,anti-Sa antibody and RF among them,and statistical analysis was carried out to explore their sensitivity and specificity for diangonsing RA.Results There were significant differences between anti-CCP + anti-Sa + RF combined detection and anti-CCP, anti-Sa, RF single detection in detection sensitivity and specificity( P < 0.05 ).The sensitivity of combined detection of RA patients with disease course of < 1 year was 95.6% and with disease course of ≥ 1 year was 90.4% ,and there was significant differences ( P <0.05 ).Conclusion Anti-CCP,anti-Sa and RF are good indexes for early RA diagnosis , combination of the three is better for improving its sensitivity and diagnosis rate, which is applicable for the early screening of RA.