Rho/Rho激酶信号通路与中枢神经系统炎性脱髓鞘病

摘要

Rho/Rho-kinase are ubiquitously expressed proteins in intraoelluar signal transdurtion pathways. Rho/Rho-kinase signalling pathways participate in diverse cellular biological behaviors through kinase cascades regulating polymerization of micrafilament pytoskeleton in cell. Rho/Rho-kinase pathway plays an important role in central nervous system(CNS ) inflammatory demyelinating disease in pathogenesis. Inhibition of Rho/Rho-kinase signalling pathways leads to a neuroprotective eiifect. Here is to make a review on the advances in the study of the biological characteristics of the signaling pathway and its role in CNS inflammatory demyelinating disease.%Rho/Rho激酶信号通路是各组织细胞中普通存在的一条信号通路,通过激酶级联反应调节细胞内微丝骨架的聚合状态,参与细胞多种生物学行为.Rho/Rho激酶信号通路在中枢神经系统(CNS)炎性脱髓鞘病的发病机制中发挥了重要作用,抑制Rho/Rho激酶信号通路可起到神经保护作用.该文就该信号通路的生物学特征及其在CNS炎性脱髓鞘病中作用的研究进展予以综述.