系统性红斑狼疮合并冠心病的发病机制及治疗的研究进展

摘要

Systemic lupus erythematosus( SLE ) is a autoimmune diseases with higher incidence. Heart disease is an important clinical manifestations of SLE, and coronary artery disease is the most important complication of heart damage of SLE patients. SLE patients have obviously increased risk for coronary artery disease, which might be the result of multiple pathogenic mechanisms including arteriosclerosis,vasculitis or an-ti-phospholipids. Ischemic heart disease is a major cause of death of SLE patients. The most effective treatment for those patients is control of risk factors and revascularization.%系统性红斑狼疮(SLE)是一种发病率较高的自身免疫疾病.心脏损害是SLE重要的临床表现之一,SLE可累及心脏的各个部分,而冠状动脉疾病是SLE心脏损害中最重要的一种.患者冠状动脉性心脏病的危险性显著增加,其原因可能是动脉硬化、血管炎性反应或抗磷脂抗体的作用.缺血性心脏病是SLE致死的主要原因,控制危险因素和血运重建是有效的治疗方法.