血清降钙素原测定在儿童感染性疾病中的应用

摘要

目的：探讨血清降钙素原( PCT)检测在儿童感染性疾病中的应用价值。方法回顾新疆自治区人民医院北院2010年1月至2012年1月收治的180例患感染性疾病儿童临床资料,对细菌培养情况、PCT、血清C反应蛋白(CRP)和白细胞计数(WBC)结果进行分析。依据细菌培养结果分组,细菌培养结果阳性即为细菌感染组(100例),细菌培养结果阴性为非细菌感染组(80例)。结果180例患儿中,非细菌感染组血清PCT、CRP和WBC阳性率分别为5.0%(4/80)、72.5%(58/80)和7.5%(6/80),细菌感染组血清PCT、CRP和WBC 阳性率分别为90.0%(90/100)、84.0%(84/100)和36.0%(36/100),显示细菌感染组血清PCT阳性率明显高于非细菌感染组,而CRP阳性率在细菌感染组和非细菌感染组中差异不显著,细菌感染组WBC阳性率明显低于PCT阳性率。 PCT阳性率与细菌感染程度呈正相关。结论作为区分细菌感染和非细菌感染的重要指标,患儿血清PCT检测对细菌感染性疾病的诊断明显优于CRP和WBC检测,PCT与患儿感染程度呈正相关,可作为疗效和预后评估指标。%Objective To evaluate the serum procalcitonin ( PCT) detection in children. with infectious diseases. Methods The 180 serum samples of children suffering from infectious diseases was collected in the Xinjiang Autonomous Region People′s Hospital North Hospital from 2010 Jan to 2012 Jan Among of them,100 samples whose bacterial culture were positive were defined into the bacterial infection group,80 were negative for non-infection group. All Serum PCT was measured by semi-quantitative solid-phase immu-noassay,C-reactive protein (CRP) was detected by immune nephelometry,with blood cell (WBC) was checked by regular instruments. Results PCT,CRP and WBC positive rate was 5. 0%(4/80),72. 5%(58/80) and 7. 5%(6/80),in the non-bacterial infection group respectively they were 90. 0 %(90/100), 84. 0%(84/100) and 36. 0%(36/100) in the infection group,The PCT positive rate of bacteria-infection group was significantly higher than non infection,group,but no statistical difference with CRP. The WBC pos-itive rate was significantly lower than the PCT. in the infection group. All results showed. that the positive rate of bacterial PCT is closely related to the severity of infection. Conclusion As an important indicator for the bacterial infected or not,the serumPCT is better than CRP and WBC ,and which has close relationship with the infection severity in children,The serum PCT is a good candidate to predict the treatment effect and make a prognosis.