丙戊酸钠缓释片与碳酸锂治疗双相障碍Ⅰ型躁狂发作的疗效及安全性对比

摘要

Objective To explore the efficacy and safety of valproate zyban and lithium carbonate in the treatment of type Ⅰ bipolar manic.Methods During Aug.2012 and Aug.2013 in Division of Shanghai Mental Health Center, 86 cases of type Ⅰ bipolar manic patients were included in the study , and were divided into valproate zyban group and lithium carbonate group according to random-number table method,43 cases in each group.The therapeutic effect and adverse reactions of the two groups were observed.Results The total efficiency of valproate zyban group was 83.72%, of lithium carbonate group was 86.05%,the difference was not statistically significance(P>0.05).Before and 1 week after treatment,2 weeks after treatment,4 weeks after treatment the BRMS rating scaleof the two groups had no statistically significant difference(P>0.05).The incidence of adverse reactions of valproate zyban group was 32.56%,which was significantly lower than that of lithium carbonate group(88.37%),and there was statistically significant difference between the two groups(P<0.05).Conclusion Efficacy of valproate zyban treatment of manic episode of type Ⅰ bipolar disorder is similar to lithium carbonate treatment ,while the adverse reactions during medication is significantly reduced ,therefore it should be vigorously promoted in clinical .%目的：探讨丙戊酸钠缓释片与碳酸锂治疗双相障碍Ⅰ型躁狂发作的疗效及安全性。方法选择2012年8月至2013年8月在上海市精神卫生中心分部治疗的双相障碍Ⅰ型躁狂发作患者86例，按随机数字表法将其分为丙戊酸钠组和碳酸锂组，每组各43例，碳酸锂组给予碳酸锂治疗，丙戊酸钠组给予丙戊酸钠缓释片治疗。观察两组的治疗效果及不良反应情况。结果丙戊酸钠组的总有效率为83．72％，碳酸锂组为86．05％，差异无有统计学意义（P ＞0．05）。两组患者治疗前、治疗后1周、治疗后2周、治疗后4周躁狂量表评分比较，差异无统计学意义（P＞0．05）。丙戊酸钠组治疗期间总不良反应发生率较碳酸锂组显著降低（32．56％ vs 88．37％），差异有统计学意义（P＜0．05）。结论采用丙戊酸钠缓释片治疗双相障碍Ⅰ型躁狂发作疗效与服用碳酸锂治疗相当，服药期间不良反应显著减少，值得在临床上大力推广使用。