血浆脑钠肽及N端脑钠肽前体与心力衰竭的研究新进展

摘要

Chronic heart failure is a common clinical cardiovascular disease with a high incidence ,and can be accompanied with sudden death,arrhythmia and other cardiovascular diseases.Plasma brain natriuretic pep-tide (BNP) and N-terminal pro-BNP(NT-proBNP) are currently available as a polypeptide with a variety of biological functions of hormones for disease of heart failure,ischemic cardiomyopathy,hypertension,and pulmo-nary heart disease,playig the role of diuresis,natriuresis,expanding the tube through the heart capacity,load and ventricular wall tension.BNP/NT-proBNP can be used as the detection index of cardiovascular diseases.%慢性心力衰竭是临床上常见的心血管疾病，可伴发猝死、心律失常等其他心血管疾病，具有较高的发病率。血浆脑钠肽（BNP）及 N 端 BNP 前体（NT－proBNP）目前可作为心力衰竭、缺血性心肌病、高血压以及肺源性心脏病等疾病一种具有多种生物功能的多肽类激素，能够通过心脏的容量、负荷以及室壁张力而发挥利尿、排钠、扩管的作用。 BNP／NT－proBNP可作为心血管疾病的检测指标。