Objective To investigate the correlation between the severity of liver cirrhosis and serum thyroxine,total bile acid,CA125.Methods A total of 98 patients with liver cirrhosis treated in gastroenter-ology department of Cixian People′s Hospital from Jun.2011 to Jun.2013 were collected, and they were divided into mild group(n=40),moderate group(n=32),severe group(n =26) according to Child-Pugh score,while another 28 healthy persons who for physical examination during the same period were inlcuded as healthy control group(n=28),then the serum thyroxine,total bile acid,CA125 level of the three groups were compared and analyzed.Results The serum TT4 ,TT3 ,FT3 ,FT4 levels of patients in the mild group ,moder-ate group and severe group were respectively[(81.6 ±14.6) nmol/L,(1.6 ±0.3) nmol/L,(2.6 ±1.3) pmol/L,(9.8 ±3.5) pmol/L;(71.3 ±12.4) nmol/L,(1.0 ±0.2) nmol/L,(1.7 ±0.8) pmol/L,(7.1 ± 3.3) pmol/L;(52.7 ±11.5) nmol/L,(0.8 ±0.1) nmol/L,(1.2 ±0.4) pmol/L,(5.1 ±2.7) pmol/L], which were significantly lower than those in the control group[(120.9 ±18.3) nmol/L,(1.9 ±0.4) nmol/L, (6.7 ±2.3) pmol/L,(16.5 ±5.9) pmol/L],those in the moderate group were lower than those in the mild group,those in the severe group were lower than those in the moderate group (P<0.05);the serum total bile acid levels in the mild group,moderate group and severe group were (30.8 ±10.3),(41.2 ±12.3), (56.2 ±14.0) μmol/L respectively,which were significantly higher than those in the control group[(6.1 ± 1.9)μmol/L](P<0.05),that in the moderate group was significantly higher than that in the mild group, that in the severe group was significantly higher than that in the moderate group ( P <0.05 );the serum CA125 in the mild group,moderate group and severe group were (2.3 ±0.5),(4.3 ±1.1),(23.9 ±9.1) kU/L respectively,which were significantly higher than that in the control group(1.0 ±0.5) kU/L(P <0.05);that in the moderate group was significantly higher than that in the mild group ,that in the severe group was significantly higher than that in the moderate group ( P<0.05 ) .The cirrhosis severity was nega-tively correlated with serum TT4,TT3,FT3,FT4(r =-0.548,-0.472,-0.615,-0.523,P =0.000), but was positively correlated with total bile acid,CA125 levels(r=0.671,0.714, P=0.000).Conclusion Serum thyroxine,total bile acid and CA125 can be used as auxiliary indexes to Child-Pugh classification method for severity of liver cirrhosis,which is helpful to accurate assessment of the severity and prognosis.%目的：探讨肝硬化严重程度与血清甲状腺素、总胆酸、癌抗原125（CA125）水平的相关性。方法收集2011年6月至2013年6月在磁县人民医院内五科就诊的肝硬化患者98例，根据Child－Pugh评分分为轻度组（40例），中度组（32例），重度组（26例），另选同期健康体检者28例设为健康对照组（28例），比较分析4组血清甲状腺素、总胆酸、CA125水平。结果轻度组患者血清总甲状腺素（ TT4）、总三碘甲状腺原氨酸（ TT3）、游离三碘甲状腺原氨酸（ FT3）、游离甲状腺素（ FT4）水平分别为（81．6±14．6） nmol／L、（1．6±0．3） nmol／L、（2．6±1．3） pmol／L、（9．8±3．5） pmol／L，中度组患者血清TT4、TT3、FT3、FT4水平分别为（71．3±12．4） nmol／L、（1．0±0．2） nmol／L、（1．7±0．8） pmol／L、（7．1±3．3） pmol／L，重度组分别为（52．7±11．5） nmol／L、（0．8±0．1） nmol／L、（1．2±0．4） pmol／L、（5．1±2．7） pmol／L，均显著低于对照组[（120．9±18．3） nmol／L、（1．9±0．4） nmol／L、（6．7±2．3） pmol／L、（16．5±5．9） pmol／L]，中度组低于轻度组，重度组低于中度组（P＜0．05）；轻度组、中度组、重度组血清总胆酸水平分别为（30．8±10．3）、（41．2±12．3）、（56．2±14．0）μmol／L，均明显高于对照组[（6．1±1．9）μmol／L]（P ＜0．05），中度组明显高于轻度组，重度组显著高于中度组（P ＜0．05）；轻度组、中度组、重度组肝硬化患者血清CA125水平分别为（2．3±0．5）、（4．3±1．1）、（23．9± 9．1） kU／L，显著高于对照组（1．0±0．5） kU／L （P＜0．05）；中度组明显高于轻度组，重度组明显高于中度组（P＜0．05）。肝硬化严重程度与血清 TT4、TT3、FT3、FT4呈负相关（r＝－0．548，－0．472，－0．615，－0．523，均 P ＝0．000 ），而与总胆酸、CA125水平呈正相关（ r ＝0．671，0．714，均 P ＝0．000）。结论血清甲状腺素、总胆酸及CA125可作为肝硬化严重程度Child－Pugh分级法的辅助指标，有助于准确评估病情和预后。
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