肿瘤性高钙血症患者血浆离子钙及总钙检测的诊断意义

摘要

目的：探讨肿瘤性高钙血症患者血浆离子钙和总钙检测的意义。方法选择宝鸡市中心医院2011年4月至2013年4月收治的恶性肿瘤患者93例为观察组，选择同期健康体检者87例为对照组。分别抽取两组受试者的空腹静脉血，进行离子钙、pH、总钙、清蛋白水平的检测，并计算两组校正离子钙（ nICa）水平和校正钙值（ cTCa）。结果两组受试者总钙水平差异无统计学意义（ P ＞0．05）。而观察组的cTCa水平、nICa水平和pH显著高于对照组，清蛋白和离子钙水平显著低于对照组，差异均有统计学意义（均P＜0．05）。观察组cTCa和nICa阳性率均显著高于对照组，差异有统计学意义（ P＜0．05）。17例高钙血症患者中以肺癌患者最多，其次是肠癌，再次为卵巢癌和胰腺癌，乳腺癌、宫颈癌以及淋巴瘤。结论通过测定nICa水平和总钙水平，可以对肿瘤性高钙血症患者进行早期诊断，从而早期进行治疗，改善患者的临床症状，提高患者临终生活质量。%Objective To investigate the significance of detection of plasma ionized calcium and total calcium in patients with neoplastic hypercalcemia .Methods A total of 93 patients with malignant tumor admitted in Baoji Central Hospital from Apr.2011 to Apr.2013 were selected as the observation group,anoth-er 87 cases of healthy people underwent physical examination during the same period were selected as the control group.Fasting venous blood of the patients in both groups were drawn to detect the levels of ionized calcium,pH,total calcium,albumin,and levels of corrected ionized calcium levels( nICa) and corrected cal-cium (cTCa) of the two groups were calculated.Results Total calcium levels of the two groups had no sta-tistically significant difference(P>0.05).Levels of cTCa,nICa and pH of the observation group were signif-icantly higher than those of the control group ,and albumin and ionized calcium levels of the observation group were significantly lower than those of the control group , the differences were statistically significant ( P <0.05).The cTCa and nICa positive rates of the observation group were significantly higher than those of the control group,the differences were statistically significant(P <0.05).Patients with lung cancer accounted the most among the 17 patients with high calcium hematoma,followed by colon cancer,ovarian cancer,pan-creatic cancer,breast cancer,cervical cancer and lymphoma.Conclusion Through detecting the levels of corrected ionized calcium and total calcium , patients with neoplastic hypercalcemia can be early diagnosed and treated,thus the clinical symptoms and quality of life of the dying patients can be improved.