转化生长因子β介导腹膜粘连形成的分子机制研究进展

摘要

Peritoneal adhesion formation after abdominal surgery is still a difficult problem to conquer .A large number of studies indicated that transformation growth factor β( TGF-β) played a key role in postopera-tive peritoneal adhesions.In Recent years,a lot of scholars have made in-depth researches about molecular mechanism of peritoneal adhesion mediated by TGF-β.Here is to briefly summarize the TGF-βpathway which promote adhesion formation,such as Smads,MAPK and RhoA GTPase/ROCK,in order to provide potential targets for the prevention from postoperative peritoneal adhesion.%手术后形成的腹膜粘连是腹部外科难以攻克的课题。大量研究证实，转化生长因子β（ TGF－β）在术后腹膜粘连的形成中具有重要作用。近年来，大量学者就TGF－β介导腹膜粘连形成的分子机制进行了多方面的研究。该文简单概述 TGF－β通过 Smads、丝裂原活化蛋白激酶和 RhoA GTPase／ROCK等信号通路介导腹膜粘连的形成，以期为术后腹膜粘连的预防提供潜在的靶点。