丁苯酞注射液联合依达拉奉对脑梗死损伤的保护作用

摘要

Objective To investigate the protective efficacy of butylphthalide sodium chloride injection plus edaravone for cerebral infarction ischemia-reperfusion injury.Methods Total of 60 patients with acute cerebral infarction admitted to Wuhu Second People′s Hospital from Mar.2015 to Mar.2016 were divided into a control group and an observation group according to the random number table method,30 cases each. The control group was given Bayaspirin(100 mg/d),edaravone(30 mg added to 100 mL normal saline infu-sion,twice daily);the observation group received add-on butylphthalide sodium chloride injection (100 mL static drop,twice daily),the treatment cycle was 28 days.The National Institutes of Health stroke score (NIHSS),modified Barthel index(MBI) of the two groups before and after treatment were compared,and the clinical efficacy was compared.Results After 7,14,21,28 d of treatment,NIHSS of both groups were decreased, the observation group lower than the control group,with statistically significant difference ( P <0.05).After 7,14,21,28 d of treatment,MBI scores of both groups rose,7,14,21,28 d,and the observation group was higher,the difference was statistically significant(P<0.05).Total effective rate of the observation group was higher than the control group[86.7%(26/30) vs 56.7%(17/30)],the difference was statisti-cally significant(P <0.05).Conclusion Butylphthalide injection plus edaravone is safe and effective in treatment of cerebral ischemia-reperfusion injury,with distinct clinical curative effect.%目的：探讨丁苯酞注射液联合依达拉奉用药对脑梗死损伤的保护作用。方法选取2015年3月至2016年3月芜湖市第二人民医院收治的脑梗死患者60例，采用随机数字法分为对照组和观察组，各30例。对照组患者给予拜阿司匹林（100 mg／d）、依达拉奉（30 mg）加入0.9％氯化钠注射液100 mL，静脉滴注，每日2次；观察组在此基础上加用丁苯酞氯化钠注射液100 mL，静脉滴注，每日2次。两组疗程均为28 d。对比两组患者治疗前后美国国立卫生研究院脑卒中量表评分（ NIHSS）、改良Barthel指数（ MBI）评分，并比较两组治疗后的临床疗效。结果治疗后7、14、21、28 d，两组患者NIHSS均呈下降趋势，且观察组治疗后7、14、21、28 d NIHSS 低于对照组，差异有统计学意义（ P ＜0.05）。治疗后7、14、21、28 d，两组患者MBI评分呈上升趋势，且观察组治疗后7、14、21、28 d MBI评分高于对照组，差异有统计学意义（ P ＜0.05）。观察组总有效率高于对照组[86.7％（26／30）比56.7％（17／30）]，差异有统计学意义（P＜0.05）。结论丁苯酞注射液联合依达拉奉用药对脑梗死损伤具有良好的保护作用，临床疗效显著。