瘦素与急性胰腺炎相关性的研究进展

摘要

Acute pancreatitis( AP) is a common disease with various complications and high mortality rate.Its pathogenesis is complex,upon which no thorough illustration has been achieved.Obesity is a risk fac-tor for AP and can be used as one of the evaluation index for AP severity .Leptin is an hormone derived from adipose tissue that acts centrally in the hypothalamus to regulate body waste and peripherial energy metabo-lism.The relationship between leptin and AP has been chosen as research topics by many scholars recently . Some researches confirmed that the increased leptin has a close relationship with the severity and prognosis of AP.At the same time,leptin can protect the pancreas and intestinal barrier dysfunction,reduce liver failure and lung injury in AP.Leptin,obesity and pancreatitis are closely associated.%急性胰腺炎（ AP）是临床常见的急腹症，常并发肝脏、肺以及肠屏障功能的损伤，病死率较高，且发病机制复杂，目前尚未完全阐明。瘦素作为一种重要的调节脂肪沉积和能量代谢的细胞因子，与AP的关系已经引起了学者的广泛关注。 AP患者体内瘦素含量升高，与AP的严重程度和预后关系密切。瘦素可通过多种方式保护胰腺组织和肠黏膜屏障功能，减少肝损伤、肺损伤等。此外，瘦素、肥胖与胰腺炎之间联系紧密。