泛素-蛋白酶体系统在心肌肥厚中的研究进展

摘要

泛素-蛋白酶体系统（ UPS）是真核细胞内蛋白质降解的主要途径之一。 UPS参与真核细胞的许多生物学功能（如炎症、细胞信号转导、转录调控以及细胞凋亡等）。心肌肥厚是导致多种心血管疾病发病率和病死率升高的独立危险因素之一。心肌肥厚的发生机制极其复杂，蛋白酶体可在心肌肥厚模型中被激活，而蛋白酶体抑制剂能阻止或逆转心肌肥厚。%The ubiquitin-proteasome system(UPS) is involved in the degradation of most intracellular proteins.It has become clear that the UPS fulfills an important function in most aspects of eukaryotic cells , such as inflammation,intracellular signaling,transcriptional control and apoptosis.Myocardial hypertrophy is one of the independent risk factors raising cardiovascular disease morbidity and mortality .The mechanism of cardiac hypertrophy is extremely complex,and its′found that proteasome can be activated in cardiac hypertro -phy models,and the proteasome inhibitor can prevent and reverse cardiac hypertrophy.