脂蛋白相关磷脂酶A2与冠心病的相关性研究进展

摘要

Lipoprotein associated phospholipase A2(Lp-PLA2),involved in the formation of atheroscle-rosis,is an enzyme mainly produced by macrophages and attached to low density lipoprotein.Lp-PLA2 activity is influenced by genetic and environmental factors.Lp-PLA2 is an independent risk predictor for patients with coronary heart disease( especially for patients with high risk ) .There is a certain correlation between Lp-PLA2 and carotid plaque and ischemic stroke.The decrease of Lp-PLA2 activity is positively correlated with the decrease of the cardiovascular events after treatment with statins.Phase three clinical trials of Lp-PLA2 inhib-itors( darapladib) did not reach the primary clinical end point.%脂蛋白相关磷脂酶A2（ Lp-PLA2）是主要由巨噬细胞等炎性细胞分泌并与低密度脂蛋白结合，参与动脉粥样硬化形成的炎症过程。 Lp-PLA2的活性受遗传和外环境等多因素影响，它是冠心病患者（尤其是中、高危患者）的独立危险预测因子。 Lp-PLA2与颈动脉斑块及缺血性脑卒中有一定相关性。他汀类药物降低心血管事件与其降低Lp-PLA2活性呈正相关，Lp-PLA2抑制剂（ darapladib）的Ⅲ期临床试验也未达主要临床终点。