内脏脂肪组织中调节性T细胞的研究进展

摘要

Regulatory T( Treg) cell can regulate and suppress the immune response,which plays a fun-damental role in maintaining immune homeostasis in vivo .Visceral adipose tissue-resident Tregs( Such as the retina,epididymis adipose tissue,etc.) are distinct from their counterparts in lymphoid organs on the pheno-type,numbers and function.Tregs are abundant in visceral adipose tissue of normal mice,but their number is greatly reduced in obese mice.They are in crucial control of obese-induced adipose tissue inflammation and metabolic disorders,which represent a potential novel strategy for treating obesity,type 2 diabetes and other metabolic syndrome.%调节性T（ Treg）细胞是一群具有免疫抑制功能的T细胞亚群，参与维持体内免疫稳态。近来研究发现，内脏脂肪组织（如网膜、附睾脂肪组织等）中 Treg细胞在表型、数量及功能上与淋巴组织不同。而且Treg细胞在正常小鼠内脏脂肪组织中大量存在，而在肥胖小鼠中数量明显减少，在肥胖导致的脂肪组织炎症及代谢紊乱中起重要调控作用，为治疗肥胖、2型糖尿病及其他代谢综合征提供新思路。