金黄色葡萄球菌生物膜形成机制及相关感染治疗的研究进展

摘要

金黄色葡萄球菌为革兰阳性致病菌,也是引起医院感染的常见化脓性病原菌;易在机体组织器官或某些惰性材料表面形成生物膜,使感染反复发作且难以控制.生物膜为细菌适应生存环境的一种保护性生存方式,与浮游菌相比生物膜内的细菌极易产生耐药性,且能抵抗宿主的防御机制,导致慢性持续性感染,给临床治疗带来极大的挑战.深入研究生物膜形成的调控机制,对积极寻找特异性的治疗方法至关重要.%Staphylococcus aureus ( SA) is a Gramp-ositive pathogen a,nd also the common suppurative pathogenic bac -teria in nosocomial infection .SA easily colonizes on both tissues and organs or inert material surfaces and form biofilms , making the infection break out repeatedly and hard to control .Biofilm is a protective way of life for the bacteria to adapt to the environment .In SA biofilm infections ,this may be more antibiotic tolerance compared with planktonic .Biofilm can resist the host defense mechanism and cause chronic persistent infections that are difficult to cure ,bringing great challenge to the clinical treatment .The study of molecular mechanism of biofilm formation is of great significance for finding specific preven -tion and treatment of biofilm related infection .