炎性衰老在骨关节炎发生中的作用

摘要

骨关节炎作为一种退行性疾病严重影响着患者的生活质量,多种炎性因子参与形成的全身性的炎症状态加速了骨关节炎的进展,最终导致关节疼痛和身体功能的下降.“炎性衰老”这一概念被认为是理解骨关节炎发生的重要方式.软骨细胞衰老退变并通过表达衰老相关分泌表型最终导致骨关节炎的发生.代谢异常疾病——也可以理解为通过炎性衰老状态影响骨关节炎的发生.通过“炎性衰老”这一新角度认识与理解骨关节炎的发生将为骨关节炎的预防和治疗提供新的思路及方法.%Osteoarthritis is a degenerative disease that seriously affects the quality of life of the patients.A variety of inflammatory factors involved in the formation of systemic inflammatory state accelerate the progression of osteoarthritis,and ultimately lead to the joint pain and decline of physical function.The concept of "inflammatory aging" is considered to be an important way for understanding the pathogenesis of osteoarthritis.The degeneration of cartilage cells and the expression of senescence-associated secretory phenotype eventually lead to the occurrence of osteoarthritis.Metabolic disorders can also be understood to affect the occurrence of osteoarthritis through inflammatory aging.Understanding the occurrence of osteoarthritts from the new perspective of inflammatory aging may provide new ideas and methods for the prevention and treatment of osteoarthritis.