肿瘤抑制基因p53在抑制肿瘤生成中起重要作用.作为p53的主要负性调节因子,鼠双微体(MDM)2能够泛素化降解p53蛋白并降低其活性,而p53则与MDM2的P2启动子序列结合,抑制其转录活性,降低其表达,两者相互作用形成负反馈环.MDMX,又称MDM4,其能够抑制p53的转录激活,调节MDM2的E3连接酶活性,且MDM2与MDMX均具有p53非依赖性致瘤作用.因此探究p53-MDM2、MDMX的相互作用及具体的作用机制可为肿瘤治疗提供新的方向.%The tumor suppressor p53 gene plays an important role in tumor formation.Murine double minute (MDM) 2 mediates the degeneration of p53 and decreases the expression of p53 through its E3 ubiquitin ligase activity.And p53 binds to the P2 promoter to inhibit the transcription of MDM2,thus form a negative feedback loop.MDMX inhibits the transcriptional activity of p53,and it can also regulate the E3 ubiquitin ligase activity of MDM2.Both MDM2 and MDMX have p53independent tumorigenic effect.Therefore,exploring the interaction between p53-MDM2 and MDMX and its specific mechanisms of action may provide a new direction for tumor therapy.
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