生殖道感染与宫颈癌

摘要

持续性高危人乳头瘤病毒(HPV)感染是宫颈癌前病变和宫颈癌发生的必要条件.一些病原体如衣原体、毛滴虫等引起的生殖道感染是阻止HPV自发清除和促进肿瘤进展的共同因素;然而,它们在宫颈癌发病机制中的具体作用尚不明确.多数学者倾向于认为细菌性阴道病、阴道毛滴虫及沙眼衣原体等感染可能通过提高下生殖道对HPV感染的敏感性在宫颈癌前病变及宫颈癌的发生过程中起作用.由于多数研究存在一定的局限性,有必要进一步研究各种常见的生殖道感染与HPV感染和宫颈癌前病变、宫颈癌之间的可能联系,为宫颈癌的防治提供一个新思路.%Persistent high-risk human papillomavirus ( HPV) infection is a necessary condition for cervical precancerous lesions and cervical cancer .Some pathogens , such as chlamydia and trichomonas ,are common factors that prevent the spon-taneous elimination of HPV and the progression of the tumor .However , their specific role in the pathogenesis of cervical cancer is unclear .Most scholars tend to believe that bacterial vaginosis , trichomonas vaginalis and chlamydia trachomatis infection may play a role in the process of the occurrence of cervical precancerous lesions and cervical cancer by increasing the sensitivity of HPV infection of the reproductive tract .Because most research has certain limitation ,it is necessary to fur-ther study the possible links between common genital tract infections and HPV infection and cervical precancerous lesions and cervical cancer ,to provide a new way of thinking about the prevention and treatment of cervical cancer .