耐碳青霉烯类药物肺炎克雷伯菌的耐药机制

摘要

Carbapenem antibiotics on β-lactamase and cephalosporinase has a high degree of stability,and is the non-amide antibiotic with the most extensive antibacterial spectrum,anti-classic β-endophyte activity.In recent years,with the widespread use,the resistance rate of Enterobacteriaceae to carbapenems is on the rise,especially the detection rate of Klebsiella pneumoniae resistant to carbapenem is significantly increased,which has brought great difficulties and disease course change in clinical antibiotic treatment.The emergence of Klebsiella pneumoniae antibiotic-resistant strains has becomea serious problem,attracting the clinicians' attention.%碳青霉烯类抗生素对β内酰胺酶及头孢菌素酶具有高度的稳定性,是抗菌谱最广、抗典型β内菌活性最强的非酰胺类抗生素.近年来随着其广泛使用,肠杆菌科对碳青霉烯类药物的耐药率不断上升,尤以耐碳青霉烯肺炎克雷伯菌检出率显著增加,因此多重耐药菌的逐年增加对临床上抗菌药物的治疗带来极大困难与病程变迁.肺炎克雷伯菌抗生素耐药菌株的出现已成为一个严峻的问题,同样也引起临床医师的高度重视.