目的：荟萃分析检测尿液脂阿拉伯甘露聚糖(LAM)对结核病的诊断价值。方法收集有关研究检测尿液 LAM 诊断结核病的文献,计算纳入研究的合并敏感度、特异度等指标,绘制综合受试者工作特征曲线并计算曲线下面积。结果共纳入12篇文献,LAM 诊断结核病的合并敏感度为0.53,95℅可信区间(CI)为(0.51,0.56)；合并特异度为0.91,95℅ CI 为(0.90,0.92)；合并阳性似然比为6.28,95℅ CI 为(4.11,9.61),合并阴性似然比为0.50,95℅CI 为(0.36,0.69)；合并诊断优势比为14.84,95℅ CI 为(7.94,27.74)。 SROC 曲线下面积为0.85。结论检测尿液LAM 对结核病具有一定的诊断价值,可作为重要的结核病诊断指标。%Objective To evaluate the value of urine lipoarabinomannan (LAM) assay in diagnosis of tuberculo-sis. Methods Papers of urine LAM assay in diagnosis of tuberculosis were collected. The pooled sensitivity, specificity and other diagnostic indexes in the study were calculated. Summary receiver operating characteristic (SROC) curve was drawn, and the area under the curve was also calculated. Results Twelve research papers were included in the meta-a-nalysis. The pooled sensitivity of urine LAM assay in diagnosis of tuberculosis was 0. 53, and 95℅ confidence interval (CI) was 0. 51 -0. 56; pooled specificity was 0. 91, and 95℅ CI was 0. 90 -0. 92; positive likelihood ratio was 6. 28 with 4. 11 -9. 61 of 95℅ CI, while negative likelihood ratio was 0. 50 with 0. 36 - 0. 69 of 95℅ CI; diagnostic odds ratio was 14. 84 with 7. 94 -27. 74 of 95℅ CI. The area under the curve of SROC was 0. 85. Conclusion Urine lipoarabinomannan assay plays a certain role in diagnosis of tuberculosis, and may be a useful important diagnostic index for tuberculosis.
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