益肾安胎汤对早期先兆流产患者血清孕酮、β-HCG和PRL的影响

摘要

目的 分析益肾安胎汤对早期先兆流产患者血清孕酮、β-人绒毛膜促性腺激素(β-HCG)和催乳素(PRL)的影响.方法 回顾性分析2013年11月—2015年10月诊治的100例早期先兆流产患者的临床资料.根据治疗方式的不同分为联合组和对照组,每组50例.对照组给予HCG和黄体酮治疗,联合组在对照组的基础上给予益肾安胎汤治疗.比较并分析两组治疗前后的血清孕酮、β-HCG和PRL水平及治疗后的妊娠结局、治疗效果和不良反应发生情况等.结果 治疗后,两组血清孕酮、β-HCG和PRL水平高于治疗前(P<0.05),且联合组高于对照组(P<0.05).联合组流产率低于对照组(P<0.01),足月妊娠率和治疗总有效率明显高于对照组(P<0.01,P<0.05).两组的不良反应总发生率比较差异无统计学意义(P>0.05).结论 益肾安胎汤治疗早期先兆流产可明显的改善孕妇血清孕酮、β-HCG和PRL激素水平,降低流产率,提高足月妊娠率,而且在临床症状的改善方面效果显著,无严重不良反应.%Objective To investigate effects of Yishen Antai Decoction on serum progesterone ( P) , β-human chorionic gonadotropin (β-HCG) and prolactin ( PRL) of patients with early threatened abortion. Methods Clinical da-ta of 100 patients with early threatened abortion admitted during November 2013 and October 2015 was retrospectively an-alyzed, and the patients were divided into combined group and control group according to different treatment methods ( n=50 for each group) . Control group was treated with HCG and progesterone, while combined group was treated with Yishen Antai Decoction on the basis of treatment for control group. Changes of serum P,β-HCG and PRL before and after treatment, pregnancy outcomes, curative effect and adverse reactions were compared and analyzed in two groups. Results After treatment, serum P, β-HCG and PRL levels were significantly higher than those before treatment in two groups (P<0. 05), and the levels in combined group were significantly higher than those in control group (P<0. 05). In com-bined group, abortion rate was significantly lower (P<0. 01), while rate of full-term pregnancy and total effective rate in combined group were significantly higher than those in control group (P<0. 01, P<0. 05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0. 05). Conclusion Yishen Antai De-coction can significantly improve the serum P,β-HCG and PRL levels of pregnant women with early threatened abortion, reduce miscarriage rate and improve full-term pregnancy rate. It can significantly improve clinical symptoms without seri-ous adverse reactions.