支原体肺炎患儿血清IL-6、IL-10、TNF-α、CRP水平变化

摘要

Objective:To investigate the changes of serum IL-6, IL-10, TNF-α and CRP in children with mycoplasma pneumoniae pneumonia (MPP) and its clinical significance. Methods:The serum levels of IL-6, IL-10, TNF-α and CRP in 72 children with MPP during acute stage and convalescence stage were detected respectively and compared with those in control group.Results:The serum levels of IL-6, IL-10, TNF-α and CRP of children with MPP in acute stage were significantly increased compared with those in convalescence stage and control group (P < 0.01), but no significant difference between convalescence stage and control group (P > 0.05). The serum levels of IL-6, IL-10 and TNF-α of children with MPP in acute stage were positively correlated with CRP (P<0.01). Conclusions:IL-6, IL-10, TNF-α and CRP may be involved in the pathogenesis of MPP, and monitoring the changes of these cytokines can aid the judgment of disease and valuation of therapeutic efficacy of MPP.%目的：探讨肺炎支原体肺炎（MPP）患儿血清白介素6（IL-6）、白介素10（IL-10）、肿瘤坏死因子-α（TNF-α）和C-反应蛋白（CRP）的水平变化及临床意义。方法：选择MPP住院患儿72例，测定其急性期和恢复期血清IL-6、IL-10、TNF-α和CRP水平，并与对照组进行比较。结果：MPP患儿急性期血清IL-6、IL-10、TNF-α和CRP水平均高于恢复期和对照组，差异有统计学意义（P＜0.01）；恢复期与对照组间的差异均无统计学意义（P >0.05）。急性期血清CRP水平与IL-6、IL-10、TNF-α呈正相关（P＜0.01）。结论：IL-6、IL-10、TNF-α和CRP参与小儿MPP的发病过程，动态监测血清IL-6、IL-10、TNF-α和 CRP的水平变化，有助于对MPP病情程度的判断与治疗效果的评价。