4项肿瘤标志物联合检测在胃肠道疾病中的诊断价值分析

摘要

目的：探讨血清癌胚抗原（CEA）、糖类癌抗原199（CA19-9）、糖类癌抗原724（CA72-4）、糖类癌抗原242（CA242）等4项肿瘤标志物联合检测在不同肠道疾病中的诊断价值。方法：观察26例胃肠道癌患者（其中胃癌10例，结肠癌7例，直肠癌9例）和胃肠良性疾病（胃炎、肠炎、息肉）以及26例健康体检者外周血CEA、CA19-9、CA72-4、CA242的量，并进行分析、比较组间差异。结果：与健康对照组相比，胃肠道恶性肿瘤，胃肠炎症、息肉中CEA、CA19-9、CA72-4、CA242指标水平及阳性率均具有统计学差异（＜0.05） CEA、CA19-9、CA72-4、CA242联合检测在诊断胃癌、结肠癌和直肠癌中的敏感性最高，分别达到了100％、86%和100％。结论：联合检测CEA、CA19-9、CA72-4、CA2424项指标具有互补作用，能提高胃肠道疾病的检出率。%Objective: To investigate the clinical significance of combined detection of four tumor markers (CEA, CA19- 9, CA242, CA72- 4) for diagnosis of gastrointestinal disease. Methods:Detections of CEA, CA19- 9, CA242, and CA72- 4 were con-ducted in 26 cases of gastrointestinal cancers (10 cases of gastric cancer, 7 cases of colon cancer, 9 cases of colorectal cancer), 26 cases of benign disease patients (gastritis, enteritis, polyp) , and 26 cases of normal healthy individuals. The contents and positive rates of four tumor markers among them were compared. Results: Compared with healthy control group, the levels and positive rates of CEA, CA19- 9, CA72- 4 and CA242 in patients with gastrointestinal cancers and gastrointestinal inflammation and polyps ( <0.05). Conclusion:Combined detection of four tumor markers may help to improve the diagnosis of gastrointestinal disease.