目的 探讨泮托拉唑对重症高血压脑出血后上消化道出血的防治作用.方法 150例Glasgow评分(GCS)≤7分高血压脑出血患者,随机分为泮托拉唑治疗组和雷尼替丁对照组,治疗组:泮托拉唑注射剂40 mg加入生理盐水100ml中静脉滴注,2次/d；对照组:雷尼替丁150mg加入葡萄糖注射液500ml静脉滴注,2次/d.所有患者基础治疗措施相同,观察上消化道出血的发生例数及好转例敷.结果 泮托拉唑治疗组发生上消化道出血21例(28.0％),总有效率92.0％,而对照组上消化道出血达38例(50.7％),总有效率73.3％.治疗组与对照组上消化道出血发生率、总有效率差异有统计学意义(P＜0.01).结论 泮托拉唑较雷尼替丁能更有效地预防和治疗高血压脑出血并发应激性溃疡出血,泮托拉唑治疗重症脑出血后上消化道出血应做到早期、足量及足够疗程.%Objective To investigate the efficiency of pntoprezole on preventing of upper gastrointestinal bleeding in severe cerebral hemorrhage. Methods 150 patients with hypertensive intracerebral hemorrhage (GCS≤7) were randomly divided into pantoprezole group (the treatment group, 75 cases) and ranitidine group (the control group. 75 cases). The treatment group received injection of pantoprezole. The control group received injection of ranitidine. The incidence of gastrointestinal bleeding was observed. Results There were 21 cases and 38 cases with upper gastrointestinal bleeding in the treatment group and the control group. The general effective rate in the treatment group (92. 0%) were significantly higher than that in the control group (73. Z%) (P<0. 01). Conclusion Pantoprezole can effectively decrease the incidence of gastrointestinal bleeding caused by severe cerebral hemorrhage.
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