马来酸曲美布汀联合谷维素治疗肠易激综合征的疗效观察

摘要

Objective To observe the curative effect and side effect of trimebutine maleate tablets combined with bifidobiogen on treatment of irritable bowel syndrome. Methods 67 patients with irritable bowel syndrome were randomly divided into union treatment group of 34 patients treated with trimebutine maleate tablets, 200mg,tid,po and combined with bifidobiogen. 60mg,tid, po and control group of 33 patients treated with trimebutine maleate tablets by the same therapy as union treatment group. The clinical symptom of two groups was compared before and after treatment respectively,and the treatment of clinical efficacy was counted after treatment. Results The total effective rate of the union treatment group was better than that of the control group(85. 3% ,75. 8% ,P<0. 05). After treatment, the clinical symptom of union treatment group was more significant improvement than union treatment group treatment before and control group after treatment(P<0. 01,P<0. 05). Conclusion The trimebutine maleate tablets combined with bifidobiogen had a good effect on treatment of irritable bowel syndrome without adverse reaction.%目的 观察马来酸曲美布汀联合谷维素治疗肠易激综合征的临床疗效和不良反应.方法 58例肠易激综合征患者随机分成两组,联合治疗组30例,口服马来酸曲美布汀片200mg,每日3次；联合口服谷维素60mg,每日3次,疗程均为2周;对照组28例,单用马来酸曲美布汀片,用法同联合治疗组.分别比较两组治疗前后临床症状,并在治疗结束时进行临床疗效评价.结果 联合治疗组总有效率86.7％,对照组总有效率75.0％,两组比较有显著差异性(P＜0.05).联合治疗组用药后症状明显较治疗前及对照组治疗后改善(P＜0.01或P＜0.05).结论 马来酸曲美布汀联合谷维素治疗肠易激综合征疗效显著,且无明显不良反应.