Objective To study the expression of the p53 and cyclin Dl in thyroid carcinoma. Methods p53 and cyclin Dl were examined in 68 cases of thyroid carcinoma , 46 cases of adinoma and adjacent normal tissues of thyroid tumor by immunohistochemistry. Results The positive rates of p53 and cyclin Dl were 58. 82% and 63. 23% in the thyroid carcinoma, which were significantly higher than those in the adinoma and adjacent normal tissues (P<0. 01). By comparison of different pathological tissues, the positive rates of p53 and cyclin Dl were 37. 83% and 40. 54% in the papillary carcinoma, which were significantly lower than those in the follicular carcinoma, medullary carcinoma and undif-ferentiated carcinoma tissues. The positive rates of p53 and cyclin Dl in thyroid cancer was positively correlated(P< 0. 05). Conclusion The expression of p53 and cyclin Dl were related to tumor differentiation and the degree of malignancy and may indicate a poor prognosis.%目的 探讨p53和cyclin D1蛋白在甲状腺癌组织中的表达情况及其临床意义.方法 用免疫组化方法对68例甲状腺癌、46例甲状腺腺瘤和瘤旁甲状腺组织进行p53和cyclin D1的检测.结果 p53和cyclin D1在甲状腺癌组织中的阳性表达率为58.82％和63.23％,均高于其在甲状腺腺瘤和甲状腺腺瘤旁甲状腺组织中的阳性率,差异均有显著性(P＜0.01).不同病理类型甲状腺癌组织中,p53和cyclin D1在乳头状癌中的阳性率分别为37.83％和40.54％,低于其在滤泡癌,髓样癌和未分化癌组织中的阳性率,差异均有统计学意义(P＜0.05).p53和cyclin D1在甲状腺癌的阳性表达呈正相关(r=7.78,P＜0.05).结论 p53和cyclin D1在甲状腺癌组织中的表达与癌细胞分化及恶性程度似有一定的关系.
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