Objective To compare the effects of levobupivacaine combined with sufentanil for patient-controlledepidural labor analgesia. Methods 120 nulliparous parturients were enrolled in this randomized clinical trial A concentration of 0. 075％ (Group A, n=30), 0. 1％ (Group B, n=30), 0. 125％ (Group C, n=30) and 0. 15％ (Group D, n = 30) of levobupivacaine with sufentanil 0. 4μg/rnl was epidurally administered by patient-controlled analgesia mode. Effective analgesia was defined as a visual analogue scale score was ≤30 mm. Parturients demographics, sensory and motor blockade, obstetric data, side effects, and others were also observed. Effective analgesia ratios were recorded. Results There were no significant differences among groups in labor duration and mode of delivery, side effects (P＞0. 05).However, a significantly less number of effective analgesia were observed in the concentration of 0. 075％ than those of ≥ 0. 1％ within each group (P＜0. 05). Conclusion Using patient-controlled epidural analgesia, levobupivacaine of 0. 1～ 0. 125％ with sufentanil of 0. 4ug/ml produce good analgesia and safety for labor analgesia.%目的 评不同浓度的左旋布比卡因复合舒芬太尼用于产妇分娩硬膜外自控镇痛的临床效果.方法 120例拟行硬膜外分娩镇痛的初产妇随机分为4组,每组30例,分别予以0.075%(A组)、0.1%(B组)、0.125%(C组)、0.15%(D组)的左旋布比卡因+0.4μg/ml舒芬太尼进行硬膜外镇痛,VAS评分≤30 mm认为镇痛有效.记录各组病人的镇痛有效率,第一、第二产程时间、运动阻滞评分、新生儿Apgar评分以及不良反应等指标.结果 A、B、C、D组病人镇痛有效率分别为77%(23/30)、87%(26/30)、90%(27/30)和93%(28/30).D组有1例运动阻滞发生.结论 0.1%和0.125%左旋布比卡因复合0.4μg/ml舒芬太尼能够为产妇提供安全可靠的镇痛.
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