多层螺旋CT灌注成像对原发性肝癌的评价

摘要

目的 探讨多层螺旋CT灌注成像在原发性肝癌中的价值.方法 对25例原发性肝癌进行多层螺旋CT灌注成像,动态电影模式扫描,所有数据经工作站软件处理并计算组织血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transittime,MTT)、毛细血管通透性(permeability surface,PS)、肝动脉供血分数(hepatic arterial fraction,HAF),比较肿瘤组织、瘤旁组织及正常肝组灌注参数的变化.结果 肝癌组织BF、HAF 明显高于瘤旁组炽及正常肝组织,而MTT明显降低,且具有显著性差异;BV和PS值与正常组织无显著差异.结论 肝癌CT灌注参数(BF、HAF和MTT)可有效的评价原发性肝癌的血流动力学改变,具有重要临床价值.%Objective To evaluate the application value of multislice CT perfusion imaging in hepatocellular carcinoma (HCC). Methods Perfusion scans were performed with 16-slice CT in 25 patients with HCC. Contrast medium -enhanced dynamic CT was performed with a statictable position for 50 seconds, and the data were analyzed with software to calculate tissue blood flow (BF), blood volume(BV), mean transittime(MTT), permeability surface(PS), and hepatic arterial fraction(HAF). Peefusion parameters of tumor, the periphery of tumor and normal liver were compared. Results HCC showed high BF, HAF, HAP and short MTT compared with those of the periphery of HCC and normal liver.Conclusion The changes of hepatic perfusion parameters (BF, HAF and MTT) have great valueon evaluating the hemodynamics of HCC.