急性心肌梗死围PCI手术期替罗非班的应用及安全性分析

摘要

Objective To investigate the effect of tirofiban for acute myocardial infarction (AMD in PCI operation period. Methods 38 cases of AMI were randomly divided into observation group and control group with 19 cases in each group. The control group during the PCI operation period was adopted to conventional treatment, and the observation group in PCI operation period take routine treatment with tirofiban therapy. Two groups were observed in patients with platelet aggregation rate, intraoperative bleeding and postoperative adverse cardiovascular events (MACE) incidence, Results In the observation group, the platelet aggregation rate was significantly lower than that of control group (P< 0. 01), MACE were lower than those of control group (P<0. 05). The postoperative bleeding and the control group showed no significant difference (P>0. 05). Conclusion Tirofiban in AMI patients during operation period of PCI has antiplatelet aggregation effect and high safety.%目的 探讨替罗非班应用于急性心肌梗死(AMI)围PCI手术期的疗效及安全性.方法 将38例AMI患者随机分为观察组及对照组各19例,对照组围PCI手术期采取常规治疗,观察组围PCI手术期采取常规治疗加替罗非班治疗.观察两组患者血小板聚集率、术中出血情况及术后不良心血管事件(MACE)发生率.结果 观察组血小板聚集率显著低于对照组(P＜0.01),MACE发生率低于对照组(P＜0.05),术后出血情况与对照组无统计学差异(P＞0.05).结论 替罗非班用于AMI患者围PCI手术期抗血小板聚集效果好,安全性高,值得进一步研究.