目的 观察全身化疗联合顺铂胸腔灌注治疗肺癌恶性胸腔积液的近期疗效及毒副反应.方法 回顾性分析收治的42例经临床病理确诊的非小细胞肺癌伴恶性胸腔积液患者临床资料.其中联合组22例:采用胸腔置入中心静脉导管排尽胸水后给予顺铂60mg第1、8天灌注,同时静脉输注化疗药物吉西他滨1000mg/m2第1、8/21天(GP方案)或紫杉醇60～90mg/m2第1、8/21天(TP方案)；单药组20例:顺铂60mg第1、8天灌注,21天重复,共治疗3个周期,评价近期疗效、观察毒副反应.结果 42例患者均完成3个周期的治疗,可评价疗效,联合组总有效率为81.8％,单药组为60.0％.结论 联合用药方案治疗非小细胞肺癌件恶性胸腔积液疗效明显优于单药治疗(P＜0.05),且较安全,值得临床推广应用.%Objective To evaluate the clinical efficacy,adverse effects of systemic chemotherapy combined with infusion of cisplatin into thoracic cavity in the treatment of malignant pleural effusion of non-small cell lung cancer.Methods Clinical data of 42 patients with malignant pleural effusion due to non-small cell lung cancer,which were proved by pathology,were analized retrospectively.22 patients received combined therapy:infusion of cisplatin into thoracic cavity at a dose of 60mg on day 1 and day 8,along with intravenous perfusion of gemeitabine at a dose of 1000 mg/m2 on day 1 and day 8 or paelitaxel of 60-90 mg/m2 on day 1 and day 8.20 patients received single therapy:infusion of cisplatin into thoracic cavity at a dose of 60mg on day 1 and day 8.Therapy was repeated every 21 days for one cycle.The clinical efficacy,adverse effects were evaluated after 3 cycles.Results All 42 patients completed the 3 cycles of treatment.In combined group,the total effective rate of treatment was 81.8％.In single group,the effective rate of treatment was 60％.Conclusion The combined therapy for malignant pleural effusion of non-small cell lung cancer is effective and safe,which is valuable in clinical application.
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