二甲双胍联合阿托伐他汀治疗糖尿病合并高脂血症的疗效分析

摘要

Objective To investigate the therapeutic efficacy and safety of metformin combined with atorvastatin in the treatment of diabetic mellitus complicated by hyperlipidemia.Methods 142 cases of diabetic mellitus with hyperlipidemia were assigned to observation group (n =72) and control group(n=72) randomly,and the observation group received metformin combined with atorvastatin,while the control group was given metformin.All patients received 12 week course of treatment,and then the therapeutic efficacy and incidence of adverse reactions between the 2 groups were compared.Results Before treatment,there were no significant differences in the fasting glucose(FPG),2h postprandial blood glucose (2h-PG),triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) between the 2 groups(P＞0.05).After treatment,the FPG,2h-PG,TG,TC and LDL-C in the observation group were significantly lower than those in the control group,respectively (P＜0.05),but the HDL-C was significantly higher than that in the control group (P＜0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups (P＞0.05).Conclusion The metformin combined with atorvastatin is able to correct disorders of glucose and lipid metabolism in diabetic mellitus with hyperlipidemia.%目的 探讨二甲双胍联合阿托伐他汀治疗糖尿病合并高脂血症的疗效及安全性.方法 将144例糖尿病合并高脂血症患者随机分为观察组(n=72)与对照组(n=72),观察组患者接受二甲双胍联合阿托伐他汀治疗,对照组接受二甲双胍治疗.两组患者的疗程均为12周,对比分析两组患者的疗效及不良反应发生率.结果 治疗前,两组患者空腹血糖(FPG)、餐后2h血糖(2h-PG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)相比差异无统计学意义(P＞0.05).治疗后,观察组FPG、2h-PG、TG、TC、LDL-C显著低于对照组,HDL-C显著高于对照组(P＜0.05).两组患者不良反应发生率相比差异无统计学意义(P＞0.05).结论 二甲双胍联合阿托伐他汀可纠正糖尿病合并高脂血症患者的糖脂代谢紊乱.