目的 观察静脉滴注α-硫辛酸(ALA)注射液与静滴甲钴胺注射液治疗Ⅱ型糖尿病周围神经病变(DPN)临床疗效.方法 将80例患者分别用0.9％氯化钠注射液250ml加入α-硫辛酸注射液0.6静脉滴注1次/日(A组40例)与0.9％氯化钠注射液250ml加入甲钴胺注射液0.5mg静脉滴注1次/日(B组40例),共2周,对四肢皮肤溃烂,经久不愈的创面患者坚持换药、清创,观察患者临床症状缓解程度.结果 A组:显效15例,占37.5％；有效23例,占57.5％无效2例,占5％；无明显副作用,总有效率95％.B组:显效10例,占25.0％；有效19例,占47.5％；无效11,占27.5％;无明显副作用,总有效率72.5％.A组有效率明显高于B组(P＜0.05).结论 α-硫辛酸注射液治疗Ⅱ型糖尿病周围神经病变能明显改善患者临床症状,疗效确切,安全性好,可以广泛应用于临床,尤其是基层医院.%Objective To observe the clinical effects of ALA and DPN in the treatment of DPN.Methods 250ml 0.9％ sodium chloride injection + 0.6g ALA were used for intraveous drip once a day (Group A) and 250ml 0.9％ sodium chloride injection + 0.5 mg mecobalamin injection for intraveous drip once a day (Group B).The treatment lasted for 2 weeks,the patients' clinical remission status were observed.Results In Group A,15 cases were significantly effective(37.5％),23 cases were effective (57.5％),2 cases were not effective (5％) and no side-effect was observed; in Group B,10 cases were significantly effective (25％),19 cases were effective (47.5％),11 cases were not effective (27.5％)and no side-effect was observed.The effective rate in Group A (95 ％) was higher than that in Group B (72.5 ％)(P＜0.05).Conclusion ALA can obviously improve the clinical status of patients with ensured effective effects safely,which can be widely applied to the clinical treatment especially in basic level hospitals.
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