11C-CFT脑多巴胺转运体PET显像对帕金森病进展及严重程度的评价

摘要

Objective To investigate the value of 2β-carbomethoxy-3β-(4-fluorophenyl)-(N-11 C-methyl) tropane ([11C]-β-CFT) dopamine transporter (DAT) PET imaging in the assessment of the progression and severity of Parkinson's disease (PD).Methods 30 PD patients and their [11C]-β-CFT DAT PET imaging results were retrospectively analyzed.According to Hoehn-Yahr (H-Y) grade,they were divided into early stage and advanced stage.The difference of DAT uptake in the symptom onset side and contralateral side of caudate nucleus,forepart putamen and posterior putamen was compared.The correlation between DAT uptake and onset age,course of disease,H-Y grade,UPDRSⅢ,NMSS and ADL were analyzed.Results The DAT uptake in PD patients at early stage was decreased,compared with that at advanced stage.In early stage group,the reduction of tracer uptake in forepart putamen and posterior putamen trilateral to symptom onset side was more significant than the forepart putamen and posterior putamen ipsilateral symptom onset side,but in advanced stage group,there were no significant differences.The DAT uptake of striatum had a negative correlation with onset age,course of disease,H-Y grade,UPDRS Ⅲ,but it had no relationship with NMSS or ADL.Conclusion [11C]-β-CFT DAT PET imaging can help to define stage and assess the severity of PD.%目的 探讨11C-CFT脑多巴胺转运体显像对帕金森病(PD)进展及病情严重程度的评估价值.方法 回顾性分析30例临床确诊的PD病人临床和11C-CFT DAT PET显像资料,将30例PD患者按Hoehn-Yahr(H-Y)分级分为早期PD组和中晚期PD组两组,分别比较两组组内及组间的起病侧及起病对侧尾状核、前壳核、后壳核DAT摄取指数的差异.并分析摄取指数与发病年龄、病程、H-Y分级、临床运动症状评分(UPDRSⅢ)、非运动症状评分(NMSS)、日常生活活动量表评分(ADL)的相关性.结果 中晚期PD组与早期PD组比较,除起病对侧后壳核外各区域DAT摄取指数均降低.早期PD组双侧壳核比较,起病对侧DAT摄取指数减少,差异有统计学意义.其余各组起病侧及对侧比较,差异无统计学意义.纹状俸内部分脑区DAT摄取指数与PD患者发病年龄、病程、H-Y分级、UPDRSⅢ呈显著负相关,均与NMSS、ADL无相关性.结论 11C-CFT PET显像能为不同严重程度PD病人分期提供影像学依据,有助于PD的病情严重程度评估.