菊粉和金玉兰对2型糖尿病患者血糖控制和血脂代谢的影响

摘要

Objective To investigate the effects of inulin and chicory on glucose control and lipid profiles in patients with type 2 diabetes.Methods Seventy-five patients with type 2 diabetes were assigned to inulin group (n=25), chicory group (n=25), and control group (n=25) with matching gender and body mass in-dex.The three groups were all given diabetes diets, in addition, 15 g inulin and 120 g chicory daily were added in the inulin group and the chicory group, respectively.All the patients'fasting blood glucose ( FBG) , homeosta-sis model assessment of insulin resistance index (HOMA-IR), glycated hemoglobin (HbA1c), lipid profiles, aminotransferase, and creatinine were observed at baseline, 4 weeks, and 8 weeks, and the changes of all those parameters were compared.Results The numbers of patients finishing this study in the inulin, chicory, and control groups were 23, 22, and 23, respectively.At baseline, none of the parameters showed significant differ-ence among the three groups (P>0.05).At 4 weeks, the changes of FBG, HbA1c, HOMA-IR, total cholester-ol (TC), and low-density lipoprotein cholesterol (LDL-c) in the inulin group showed a decreasing trend com-pared with the control group;and the differences in changes of FBG, HbA1c, HOMA-IR, TC, and LDL-c were significant at 8 weeks (P<0.05), while the changes of other parameters showed no significant difference (P>0.05).The changes of all the parameters showed no significant difference between the chicory group and the con-trol group at 4 weeks and 8 weeks (P>0.05).Conclusions Inulin is conducive to blood glucose control and lipid profiles in type 2 diabetes, and does not affect liver and renal functions.In contrast, chicory has no signifi-cant effect on glucose control or lipid profiles in type 2 diabetes.%目的：研究菊粉和金玉兰对2型糖尿病患者血糖控制和血脂代谢的影响。方法75例2型糖尿病患者按照性别和体重指数匹配的方法分为菊粉组（n＝25）、金玉兰组（n＝25）和对照组（n＝25），3组患者均给予普通糖尿病膳食，在此基础上菊粉组每天给予菊粉15 g，金玉兰组每天给予金玉兰120 g。分别于基线期、4和8周时观察3组患者的空腹血糖（fasting blood glucose， FBG）、胰岛素抵抗指数（homeostasis model assessment of insulin resistance index， HOMA-IR）、糖化血红蛋白（glycated hemoglobin， HbA1c）、血脂、转氨酶和肌酐等指标的变化并进行比较。结果菊粉组、金玉兰组及对照组分别有23、22和23例完成研究。基线期各项观察指标3组之间差异均无统计学意义（ P＞0.05）。4周时，菊粉组FBG、 HbA1c、 HOMA-IR、总胆固醇（total cholesterol， TC）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol， LDL-c）的变化同对照组相比有降低的趋势；8周时，菊粉组FBG、 HbA1c、 HOMA-IR、 TC、 LDL-c的降低同对照组相比差异具有统计学意义（P＜0.05），其余观察指标变化的差异无统计学意义（P＞0.05）。4周和8周时，金玉兰组各项指标变化同对照组相比差异无统计学意义（ P＞0.05）。结论菊粉有益于2型糖尿病患者的血糖控制和血脂代谢，并且对肝、肾功能无影响。金玉兰对2型糖尿病患者血糖控制和血脂代谢无显著影响。