进驻不同海拔高原健康男青年肾功能的变化

摘要

目的 探讨移居不同海拔高度高原健康男青年肾功能的变化.方法 对从平原进驻海拔3700 m和5380 m 3个月的某部各10名官兵进行血尿素氮(BUN)、血清肌酐(SCr)、尿酸(UA)及胱抑素C(Cys C)检测,并与20名平原(海拔1400 m)健康男青年作对照.结果 进驻高原3个月后,高原组的BUN、SCr、UA、Cys C均明显高于平原组(P＜0.01),且随海拔高度的升高而增高(P＜0.05或P＜0.01).结论 高原低氧环境导致肾小球滤过、肾小管重吸收和分泌功能都产生相应的损害,且这种损害随着海拔高度的升高而增强.%Objective To explore the changes of renal function in healthy young men arrived at different high altitudes.Methods 10 soldiers and officers as well as other 10 ones in a troop arrived separately at 3700 m and 5380 m altitude for three months from the plain( 1400 m above sea level ) were served as high altitude Ⅰ group and high altitude Ⅱ group, respectively.Meanwhile,another 20 healthy young men in the plain were served as the control group.Blood urea nitrogen( Bun ), serum creatinine( SCr ), uric acid( UA ) and cystatin C( Cys C ) of each subject were measured and compared one another.Results The levels of Bun, SCr, UA and Cys C in the two high altitude groups were significantly higher than those in the plain group( P ＜ 0.01 ).Moreover, the levels of these indexes increased with the elevation of altitude( P ＜ 0.05 or P ＜ 0.01 ).Conclusion High altitude hypoxia can damage renal function including glomerular filtration, tubular reabsorption and secretion, and the higher the altitude is, the more the impairment are.