目的 了解我院住院患者静脉用抗菌药物临床应用特点和存在问题,为进一步规范抗菌药物使用提供依据.方法 对我院2010年11月～2011年11月静脉给药途径抗菌药物的使用情况作统计分析,并进行评估.结果 共涉及13大类75个药品种类,其中以头孢菌素类占36.02%,青霉素类占21.57%,β-内酰胺酶抑制剂类占18.93%为主;数量最多的前6位为美洛西林钠12.99%,头孢噻肟钠9.49%,头孢他啶8.38%,头孢孟多酯钠6.08%,头孢哌酮钠/他唑巴坦钠5.53%,青霉素4.59%;使用抗菌药物最多的3个科室为骨外科30.15%,泌尿外科15.69%,心血管呼吸神经肾内科15.63%.其中用量前10位的抗菌药物中,一线用药两种,使用率为8.47%,二线用药三种,使用率为30.86%,三线用药两种,使用率为10.46%.结论 我院住院患者静脉用抗菌药物选用上仍存在不合理性,应加强临床抗菌药物使用监控,提高临床合理用药水平.%Objective To study the characteristics and problems in the clinical application of antibiotics through intravenous administration among hospitalized patients in our hospital,and to provide the basis for further standardization for the use of antibiotics. Methods Statistic analysis and evaluation were made in the use of antibiotics through intravenous administration in our hospital from November 2010 to November 2011. Results There were totally 13 classes and 75 kinds of antibiotics, in which cephalosporin accounted for 36. 02% .penicillins for 21. 52% ,and beta - lactamase inhibitors for 18. 93% . The top 6 drugs accounted for the largest number were mezlocillin sodium( 12.99% ),cefotaxime sodium for injection( 9.49% ),and ceftazidime( 8. 38% ), cefamandole nafate ( 6.08% ),cefoperazone/tazobactam( 5. 53% ),and penicillin( 4. 59% ). The top 3 departments which used the most antibacterials were bone surgery( 30.05% ),urinary surgery( 15.69% ), and cardiovascular respiratory neural kidney internal medicine( 15.63% ). Among the ten antibiotics of the most use,there were two kinds of first - line treatment medicines,with the usage of 8. 47% , three kinds of second - line drugs,with the usage of 30. 86% ,and two kinds of three - line treatment drugs,with usage of 10. 46% . Conclusion Non - rational use of antibiotics still exists among the patients in our hospital. The monitoring of antibiotics in clinical use should be strengthened and the clinical level of rational drug use should be improved.
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