rhEGF凝胶防治不同放射剂量诱导的宫颈癌放射性皮炎

摘要

Objective To observe the effects of recombinant human epidermal growth factor (rhEGF) gel in the prevention of radiodermatitis of cervical cancer induced by different radiation doses in the process of cervical cancer radiotherapy.Methods A total of 85 patients with cervical cancer to receive chemotherapy were divided into a control group (n=40) and an intervention group(n=45) according to the sequence of admission time.The two groups received routine skin care,and the intervention group was simultaneously applied with rhEGF gel on the irradiation field and surrounding skin.The incidence and healing time of radiodermatitis between the two groups were compared.Results With the increase of irradiation dose,the incidence of radiodermatitis in the two groups increased accordingly.The overall incidence of radiodermatitis in the intervention group was significantly lower than that in the control group (P ＜ 0.05);with the increase of irradiation dose,the healing time in the two groups gradually extended,but the healing time in the intervention group was much shorter than that in the control group under different irradiation doses (P ＜ 0.05).Conclusion rhEGF gel can protect the skin of patients to receive cervical carcinoma radiotherapy,lower the incidence of radiodermatitis and promote the healing,and is a safe and effective preparation for preventing radiodermatitis.%目的 观察在宫颈癌放疗中,重组人表皮生长因子(rhEGF)凝胶对不同放射剂量诱导的放射性皮炎的防护作用.方法 按入院时间先后,将85例接受化疗的宫颈癌患者分为对照组40例与干预组45例,两组均接受常规皮肤护理,而干预组同时使用rhEGF凝胶涂抹照射野及周围皮肤,比较两组放射性皮炎发生率及愈合时间.结果 随着照射剂量的增加,两组放射性皮炎发生率均呈升高趋势,干预组放射性皮炎总发生率显著低于对照组(P＜0.05);随着照射剂量的增加,两组治愈时间均逐渐延长,但在各照射剂量下,干预组愈合时间均显著少于对照组(P＜0.05).结论 rhEGF凝胶对宫颈癌放疗患者的皮肤具有保护作用,可降低放射性皮炎的发生率,促进愈合,是一种安全有效的预防放射性皮炎的制剂.